43 articles - From Friday Sep 02 2022 to Friday Sep 09 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Arthritis Care Res (Hoboken) |
Association of Area-Level Heat and Social Vulnerability with Recurrent Hospitalizations among Individuals with Rheumatic Conditions. Individuals with rheumatic conditions living in areas with high vs low social and heat vulnerability had significantly greater odds of recurrent hospitalizations. Studies are needed to determine modifiable factors to mitigate risks. |
Association of systemic sclerosis with incident clinically evident heart failure. SSc is associated with a markedly higher risk of clinically evident HF, and not asymptomatic ventricular dysfunction alone. These findings provide real-world evidence suggesting the use of appropriate screening strategies to detect these lethal complications early in SSc. |
Data-driven MRI definitions for active and structural sacroiliac joint lesions in juvenile spondyloarthritis typical of axial disease; a cross-sectional international study. We propose data-driven cut-offs for active inflammatory and structural lesions on MRI typical of axial disease in JSpA that have high specificity and sensitivity using central imaging global assessment as the reference standard and excellent reliability. |
Predicting chronic opioid use among patients with osteoarthritis using electronic health record data. We found that EHR-based predictive models could estimate the risk of future COU among OA patients to help inform care decisions. Black-box methods did not have significant advantages over more interpretable models. Care should be taken when extending al models into organizations not included in model training due to high variability in performance across held-out organizations. |
| Arthritis Res Ther |
Circ0007042 alleviates intervertebral disc degeneration by adsorbing miR-369 to upregulate BMP2 and activate the PI3K/AKt pathway. circ_7042 could upregulate the expression of CDH2 and BMP2 by absorbing miR-369-3p, and the increased BMP2 activated the PI3K/Akt pathway, thus improving IDD. |
CircPRKCH modulates extracellular matrix formation and metabolism by regulating the miR-145/HGF axis in osteoarthritis. Our study demonstrated that circPRKCH promoted chondrocyte apoptosis and ECM degradation via the miR-145/HGF axis in OA, which may provide a novel target for OA treatment. |
Dersimelagon, a novel oral melanocortin 1 receptor agonist, demonstrates disease-modifying effects in preclinical models of systemic sclerosis. MT-7117 demonstrates disease-modifying effects in preclinical models of SSc. Investigations of its mechanism of action and target expression analyses indicate that MT-7117 exerts its positive effect by affecting inflammation, vascular dysfunction, and fibrosis, which are al key pathologies of SSc. The results of the present study suggest that MT-7117 is a potential therapeutic agent for SSc. A phase 2 clinical trial investigating the efficacy and tolerability of MT-7117 in patients with early, progressive diffuse cutaneous SSc is currently in progress. |
Factors secreted by monosodium urate crystal-stimulated macrophages promote a proinflammatory state in osteoblasts: a potential indirect mechanism of bone erosion in gout. Factors secreted from macrophages stimulated by MSU crystals attenuate osteoblast differentiation and induce the expression and secretion of proinflammatory mediators from osteoblasts. We suggest that bone erosion in joints affected by gout results from a combination of direct and indirect effects of MSU crystals. |
Identification of HBEGF+ fibroblasts in the remission of rheumatoid arthritis by integrating single-cell RNA sequencing datasets and bulk RNA sequencing datasets. HBEGF+ fibroblasts play a role in the remission of rheumatoid arthritis, and HBEGF has potential to become a novel biomarker for prediction of RA progress. |
Prognostic factors for the development of systemic lupus erythematosus in patients with immune thrombocytopenia. Young age (< |
Utilization of preventive services in a systemic lupus erythematosus population-based cohort: a Lupus Midwest Network (LUMEN) study. The trends of utilization of preventive services by SLE patients vary according to screening or vaccine compared with the general population. Considering these differences, we demonstrate an opportunity for improvement, particularly in cervical cancer, hyperlipidemia, and osteoporosis screenings and vaccinations. |
| Arthritis Rheumatol |
Alterations of gut microbiome, metabolome and lipidome in Takayasu arteritis. This study firstly identifies the discriminatory gut microbes in TA. Dysbiotic microbes also link to TA phenotypes directly or indirectly via metabolic and lipid modules. Further explorations on microbiome-metagenome interface in TA subtype prediction and pathogenesis are indicated. |
Development and external validation of a model predicting new-onset chronic uveitis at different disease durations in juvenile idiopathic arthritis. We present for the first time a validated prognostic tool for easily obtaining individual chronic uveitis risks for JIA patients using common clinical parameters. This model could be used by clinicians to inform patients/parents and provide guidance in choice of uveitis screening frequency and arthritis drug therapy. |
Efficacy and Safety of Botulinum Toxin in Adults with Raynaud's Phenomenon Secondary to Systemic Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Multicenter Study. Neither the primary nor secondary endpoints were reached and our results do not support any beneficial effect of palmar BTA injections to treat SSc-RP. |
Increasing Prevalence of Antinuclear Antibodies in the United States. The prevalence of ANA in the US has increased considerably in recent years. Additional studies to determine factors underlying these increases could elucidate causes of autoimmunity and enable the development of preventative measures. |
mTOR inhibition prevents coronary artery remodeling in a murine model of Kawasaki disease. Our findings demonstrate that mTOR signaling contributes to coronary artery remodeling in KD, and that targeting this pathway offers a potential therapeutic strategy to prevent or restrict this pathology in high-risk KD patients. |
Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as biomarkers in axial spondyloarthritis: observational studies from the PULSAR registry. These findings demonstrate an association of NLR and PLR with sacroiliitis and disease activity; NLR and PLR are responsive to TNFi treatment. The NLR and PLR add useful clinical information to established biomarkers and may assist in disease management. |
| Rheumatology (Oxford) |
A panel of plasma microRNAs improves the assessment of surrogate markers of cardiovascular disease in rheumatoid arthritis patients. Plasmatic expression of microRNA-24, 96, 103, 125a, 132, 146, 191, 223 and Let7a were associated with surrogate markers of CV disease and could be predictors of CV risk in patients with RA. |
Anti-PM-Scl antibodies positive patients encompass three different groups with distinct prognosis. Anti-PM-Scl-Abs associated auto-immune diseases are segregated into 3 subgroups with distinct clinical phenotype and outcomes. Skin thickening and NSIP are determinant predictors in segregation of theses populations. |
COVID-19 vaccine hesitancy in inflammatory arthritis patients: serial surveys from a large longitudinal national Australian cohort. In this study of vaccine beliefs before and during the COVID-19 pandemic, factors associated with COVID-19 vaccine hesitancy in inflammatory arthritis patients varied, depending on vaccine attitudes immediately prior to the start of the pandemic. Fixed beliefs reflected broader views about medications, while fluid beliefs were highly influenced by whether they sought out information from healthcare professionals, including rheumatologists. |
Dendritic cells drive profibrotic inflammation and aberrant T cell polarization in systemic sclerosis. Our findings suggest that functional alterations of DCs subsidize the immune mechanisms favoring the aberrant T cell polarization and profibrotic inflammation behind the clinical SSc heterogeneity. |
Immune checkpoint inhibitor-induced arthralgia is tightly associated with improved overall survival in cancer patients. If arthralgia develops after ICIs, another irAE, such as relative adrenal insufficiency, may have developed. The incidence of arthralgia was associated with better OS and patients' condition must be carefully evaluated to determine optimal management. |
Is vaccination against Covid-19 associated with autoimmune rheumatic disease flare? A self-controlled case series analysis. Vaccination against Covid-19 was not associated with increased AIRD flares regardless of prior Covid-19, AIRD type, and whether mRNA or DNA vaccination technology were used. |
Predicting lymphoma in Sjögren's syndrome and the pathogenetic role of parotid microenvironment through precise parotid swelling recording. A more precise clinical recording of PSW can improve lymphoma prediction in pSS. PSW as a very early symptom is a predictor, and a longer duration of PSW is associated with a higher risk of NHL. Since lymphoma usually localises in the parotid glands, and not in the other salivary or lachrymal glands, the parotid microenvironment appears to be involved in the whole history of pSS and related lymphomagenesis. |
Preferences for preventive treatments for rheumatoid arthritis: discrete choice survey in the UK, Germany and Romania. Effective preventive pharmacological treatments for RA were acceptable to most participants. The relative importance of treatment attributes and likely uptake of fixed treatment profiles were predicted by participant characteristics. |
Relationship between the prevalence of subclinical tenosynovitis and treatment in patients with RA in clinical remission: STARTER study. The analysis showed a lower prevalence of subclinical inflammatory manifestations detected with ultrasound imaging in those patients treated with the combination therapy than in those in monotherapy. |
Survival and Prognostic factors from a multicentre large cohort of unselected Italian Systemic Sclerosis patients. In the last decade, SSc patients have reached similar mortality of that expected in the Italian general population. Male gender, diffuse cutaneous involvement, comorbidities, and PAH with or without ILD represent the main poor prognostic factors. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Arthritis Care Res (Hoboken) |
The phases and natural history of Sjögren's disease: a new model for an old disease? We discuss potential underlying mechanisms for disease progression and the strengths and limitations of using a staged model to correlate the pathogenesis and spectrum of manifestations in SjD. Ultimately, understanding how and why some patients remain relatively stable, while others progress and develop florid systemic disease and a fraction develop lymphoma, is key to developing preventative and therapeutic treatments. |
| Arthritis Rheumatol |
Genetic influences in cancer-associated myositis. Taken that genetic factors play a role in IIM development, dissection of molecular mechanisms shared between IIM and cancer gives an opportunity to examine the role of autoimmunity in cancer development and progression. In this review, the evidence supporting the contribution of genetics to CAM will be discussed. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Rheumatology (Oxford) |
Letters to the editors and authors’ replies
| Arthritis Care Res (Hoboken) |